摘要
目的探讨非体外循环下冠状动脉搭桥术(OPCABG)围术期输注地尔硫对心肌的保护作用。方法40例择期手术患者,随机分为地尔硫组(D组)与硝酸甘油组(C组),每组20例。D组静脉给予地尔硫0.1mg·kg-1·h-1至术后24h,C组常规给予硝酸甘油0.1μg·kg-1·h-1至术后24h。分别在术毕、术后1、3、6、12和24h记录血流动力学参数,并采集血样测定血清肌钙蛋白I(cTnI)。结果与C组比较,D组的心率术后1、3、6、12、24h均较慢(P<0.05)。C组房颤4例,D组1例;C组室上性心动过速5例,D组1例。术后6h的cTnI,D组显著低于C组(P<0.05)。结论OPCABG围术期持续输注地尔硫有比硝酸甘油更好的抗缺血和抗心律失常的保护作用。
Objective To evaluate the cardioprotetive effects of diltiazem infusion in patients undergoing off-pump coronary artery bypass grafting (OPCABG). Methods A double blind, randomised study was performed on 40 OPCABG patients. Infusion of diltiazem 0. 1 mg·kg^-1· h ^-1 or nitroglycerin 0. 1 μg· kg^-1· h ^-1 was given for 24 h in group D or C, respectively. MAP, HR,ECG and cardiac troponin I(cTnI) were monitored perioperatively. Results HR was kept stable during diltiazem infusion. The values of cTnI in group D were significantly lower than those of group C (P〈 0. 05). The postoperative incidence of atrial fibrillation was significantly lower in group D(1/20)than that in group C(4/20). conclusion Dihiazem infusion provides superior anti-ischemic protection and control of supraventricular arrhythmias as compared to nitroglycerin.
出处
《临床麻醉学杂志》
CAS
CSCD
2007年第11期894-896,共3页
Journal of Clinical Anesthesiology