摘要
乙酰丹酚酸Ａ一种新型血栓素合成酶抑制剂吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）有抗血小板功能作用［１］，且能明显抑制花生四烯酸（ＡＡ）代谢产物血...
With radio thin layer chromatography and autoradiogram, the effect of acetylsalvianolic acid A (ASAA) on 14 C arachidonic metabolism by platelets was studied in vitro . ASAA was found to enhance the formation of PGE 2 and PGF 2α remarkably while inhibiting the formation of TXB 2. However, it showed no effect on the formation of 12 HETE and arachidonic utility rate. Therefore, we deduce that ASAA may be a thromboxane synthetase inhibitor.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第6期467-469,共3页
Acta Pharmaceutica Sinica
关键词
乙酰丹酚酸A
血栓素合成酶
抑制剂
Salvia miltiorrhiza
Salvianolic acid
Platelet
Arachidonic acid
Thromboxane synthetase inhibitor
