早产儿脐血瘦素和胰岛素水平测定及其临床意义

Determination of cord blood leptin and insulin levels and their clinical significances in preterm infants

目的:探讨早产儿脐血瘦素和胰岛素水平变化与宫内生长发育状态关系的临床意义。方法:选择无产、儿科合并症的早产儿29例,足月儿41例,于分娩后收集脐静脉血。采用ELISA法和Access免疫分析系统分别测定血清瘦素和胰岛素水平。结果:早产低体重儿瘦素和胰岛素水平明显低于足月儿(P<0.05)。比较胎龄>34周、体重>2000g早产儿的瘦素和胰岛素水平较其以下者均示差异有统计学意义(P<0.01,P<0.05)。结论:脐血胰岛素水平高低与瘦素水平变化在反映早产儿不同时期内的宫内营养状态呈一致性。了解早产儿出生时的瘦素和胰岛素含量对今后早产儿生存质量的监测和易发生的慢性疾病的早期干预有其一定的临床意义。

Objective ：To investigate the clinical significance of the association between fetal development and levels of leptin and insulin in preterm infants. Methods ： Venous cord blood samples of 29 preterm newborns with no perinatal complications and 41 normal full-term newborns were collected after delivery. Serum leptin and insulin concentrations were measured using ELISA and the Access immunoassay systems,respectively. Results ：The leptin and insulin levels in preterm,low birth weight infants were significantly lower than those in full-term infants（P〈0.05）.There were statistical significances of leptin and insulin levels between gestational age〉34 weeks ,birth weight 〉2000g and less than those（P〈0.01 and P〈0.05,respectively）. Conclusion：Our results indicate that insulin concentrations coincide with leptin level changes in reflecting intrauterine nutrition status at different gestational ages of preterm infants. Detecting the concentrations of leptin and insulin of prematurity at birth may be useful for monitoring survive quality and early intervention of common chronic diseases in the future.