蒙脱石纳米复合物吸附猪日粮中黄曲霉毒素B_1效果的研究

Study on Adsorption of Dietary Aflatoxin B_1 by Montmorillonite Nanocomposite in Pigs

选用120头体重(29.8±1.3)kg的"杜长大"三元杂交猪,随机分为4个处理组,每组3个重复,每个重复10头猪(公母各半)。试验猪分别饲喂基础日粮、基础日粮添加0.3%蒙脱石纳米复合物(MN)、基础日粮添加0.1 mg/kg黄曲霉毒素B1(AFB1)、基础日粮添加0.1 mg/kg AFB1和0.3%MN,试验期90 d,以研究MN缓解猪黄曲霉毒素中毒症、降低猪体组织中黄曲霉毒素B1残留量的效果,并初步探讨其作用机理。结果表明:(1)在基础日粮中添加0.1 mg/kg的黄曲霉毒素B1,显著降低了试验猪的日增重和饲料转化效率,严重损害了试验猪的肝脏功能,造成了相关指标的异常升高或降低;(2)在黄曲霉毒素B1污染的日粮中添加0.3%的MN,显著降低了黄曲霉毒素B1在猪体组织中的残留量,明显改善了试验猪的生长性能,减轻甚至消除了黄曲霉毒素B1对动物生长性能和肝脏功能等的不良影响。

Experiments were conducted to evaluate the efficacy of montmorillonite nanocomposite （MN） to protect against aflatoxicosis of pigs and to reduce aflatoxin B1 （AFB1） residues in body tissues. A total of 120 crossbred （Duroc × Landrace × Large white） weaned barrows and gilts （mean body weight （29.8 ± 1.3） kg） were identified by individual ear tags and tattoos, and randomly assigned to four treatment groups by sex （three replicates per treatment with ten pigs per replicate）. Four dietary treatments of control feed, control feed plus 0.3% MN, control feed plus 0.1 mg/kg AFB1, control feed plus 0.1 mg/kg AFB1 and 0.3% MN were fed to treatment groups for 90 days. The results showed that 1） AFB1 can significantly affect pig health and growth performance, decrease body weight gain and feed conversion ratio, injure hepatic function, then cause significant alterations of related parameters; 2） the addition of 0.3% MN to AFB1-contaminated diet can significantly reduce aflatoxin B1 residues in pig tissues, and effectively diminish the adverse effects of aflatoxin B1 on growth performance and hepatic function of pigs. [Chinese Journal of Animal Nutrition, 2007,19（6） ：742-747 ]