期刊文献+

Ⅳ型胶原在涎腺黏液表皮样癌中的表达与微血管密度的关系

下载PDF
导出
摘要 目的探讨Ⅳ型胶原表达与涎腺黏液表皮样癌(Mucoepidermoid carcinoma,MEC)临床病理的关系及其和微血管密度之间的联系。方法应用免疫组织化学方法,检测46例MEC内Ⅳ型胶原表达与微血管密度(Microvessel density,MVD),并将检测结果进行统计分析。结果Ⅳ型胶原在涎腺黏液表皮样癌中表达的强弱与癌组织的分化程度及淋巴结转移有关(P<0.05),而与患者的性别、年龄无关(P>0.05)。涎腺黏液表皮样癌的MVD与其分化程度及淋巴结转移有关(P<0.01),而与患者的性别、年龄无关(P>0.05)。结论Ⅳ型胶原表达水平及MVD与涎腺黏液表皮样癌组织的分化程度和转移相关,此结果为临床建立新的MEC预后预测因子和指导临床治疗提供依据。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第23期2317-2319,共3页 Chinese Journal of Gerontology
  • 相关文献

参考文献9

  • 1Pasco S, Ramont L, Maquart FX, et al. Biological effects of collagen Ⅰ and Ⅳ peptides[J]. J Soc Boil,2003 ;197(1) :31-9.
  • 2Ichinoe M, Mikami T, Shiraishis H, et aL High microvaseular density is correlated with high VEGF, iNos and Cox 2 expression in penetrating growth type early gastric carcinomas[J]. Histopathology,2004;45 (6) : 612-8.
  • 3王淑强,白美玲,李鹏,李秀娟,李春智,葛丽平.微血管密度与涎腺黏液表皮样癌生物学行为的关系[J].山西医科大学学报,2007,38(7):588-589. 被引量:2
  • 4Takahashi Y,Cleary KR, Mai M,et al. Significance of vesaelcount and vascular endothelial growth factor and its reptor (KDR) in testinal type gastric cancer [J]. Cancer Res,1996 ;2 :1684-97.
  • 5Galbavy S, Lukac L, Porubsky J, et al. collagen type Ⅳ in epithelial tumours of colon [ J ]. Acta Histochem ,2002 : 104:331-4.
  • 6Yantiss RK, Bosenberg MW ,Antonioli DA,et al. Utility of MMP-1 ,p53, E.-cadherin ,and collagen Ⅳ immuneohisto chemical stuins in the differenfial diagnosis of adenomas with misplaced epithetlium versus adenomas with inasive adeno carcinoma [ J ]. Am J Surg Pothole ,2002 ;26:206-15.
  • 7Havenith MG, Arends JW, Simon R, et al. Type Ⅳ collagen immunoreativity in clorcctal cancer, prognostic value of basement membrane deposition [ J ]. Cancer, 1988 ;62:2207-11.
  • 8Gasparini G, Weider N, Bevilacqua C, etal. Tumor microvessel density, P53 expression, tumor size, and peritumoral lymphatic invasionare relevant prognostic markers in node-negative breast carcinoma [ J ]. Clincal Dncology, 1994,12( 3 ) :454-66.
  • 9那万里,赵志德,寇伯君,李玉林,王梦文.膀胱移行细胞癌VEGF表达和MVD检测的临床意义[J].中华泌尿外科杂志,1999,20(12):732-734. 被引量:13

二级参考文献10

  • 1王文勇,唐红卫,张志培,高艳红,韩彬,马福成,赵一岭.CD34和血管内皮生长因子在人甲状腺癌组织中的表达及微血管密度的病理意义[J].第四军医大学学报,2005,26(15):1408-1410. 被引量:8
  • 2Warren R S,J Clin Invest,1995年,95卷,1789页
  • 3Zhang H T,J Natl Cancer Inst,1995年,87卷,213页
  • 4Takahashi Y,Cleary KR,Mai M,et al.Significance of vessel count and vascular endothelial growth factor and its receptor in intestinal type gastric cancer[J].Clin Cancer Res,1996,2:1684-1697.
  • 5Kleer LG,Griffith KA,Sabel MS,et al.RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast[J].Breast Cancer Res Treat,2005,93:101-110.
  • 6Maeda K,Chung YS,Takatsuka S,et al.Tumor angiogenesis as a predictor of recurrence in gastric carcinoma[J].Clin Oncol,1995,13:477-481.
  • 7Raspollini MR,Amunni G,Villanucci A,et al.Prognostic significance of microvessel density and vascular endothelial growth factor expression in advanced ovarian serous carcinoma[J].Int J Gynecol Cancer,2004,14(5):815-823.
  • 8Gasparini G,Weidner N,Bevilacqua C,et al.Tumor microvessel density,p53 expression,tumor size,and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma[J].Clin Oncol,1994,12(3):454-466.
  • 9Ichinoe M,Mikami T,Shiraishi H,et al.High microvessel density is correlated with high VEGF,iNOS and COX-2 expression in penetrating growth type early gastric carcinomas[J].Histopathology,2004,45(6):612-618.
  • 10姚丽青,季天海,余英豪,曾玲.淋巴结外间变性大细胞淋巴瘤微血管密度与患者预后的关系[J].实用癌症杂志,2002,17(5):537-539. 被引量:6

共引文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部