摘要
Whipple病是一种慢性、复发性的多系统受累的感染性疾病。神经系统受累在Whipple病中并不少见,国外文献报道部分Whipple病患者早期或晚期可表现出中枢神经系统(CNS)受累的症状和体征,但Whippelii菌单独侵犯CNS很少见。Whipple病往往表现为复发-缓解的病程,尤其CNS受累时。Whipple病对抗菌药物非常敏感,因此,只要早期诊断和予以抗菌药物正规治疗,往往呈现良性的病程,不会造成后遗症。本文就其发病机制、临床表现、诊断及治疗情况做一综述。
Whipple's disease, as an infectious disorder, is chronic, relapsing and multisystem -involved. The affect- ed nervous system is not rare in this disease, which has not been reported so far at home. According to the reports abroad, the pa- tients with Whipple's disease may have the symptoms and signs of affection of central nervous system (CNS) at the early or late stages. However, the condition that infection by bacterium Tropheryma whippelii simply has been rarely seen. Whipple's disease usually presents a course of elapse - relapse, especiaUy as involvement of CNS. The bacterium Tropheryma whippelii is sensitive to antibiotics. So if only an early diagnosis is made and the normal treatment with antibiotics is given, the disease commonly pres- ents a favorable course with no sequela. In this article, we review the status of pathogenesis, clinical manifestation, diagnosis and treatment of this disease.
出处
《中国全科医学》
CAS
CSCD
2007年第23期2016-2018,共3页
Chinese General Practice