化学生物学中识别与组装的若干问题被引量：3

Molecular Recognition and Self-Assembly in Chemical Biology

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摘要化学与生物学的交叉与融合产生了新学科———化学生物学,开拓了化学和生物学研究的新领域,使人类得以从分子水平来阐释生命过程,揭示生命的奥秘。分子识别和组装是体系的构筑与功能集成的基础,也是自然界生物进行信息存贮、复制和传递的基础。以此来研究构筑具有特定生物学功能的超分子体系,对揭示生命现象和过程具有重要意义。本文结合我们的研究工作从(1)谷胱甘肽过氧化物酶(GPX)模拟与底物识别;(2)医用再生材料与活性支架;(3)类病毒颗粒的组装与解组装3个方面讨论了化学生物学中的识别与组装的意义。 The merge of chemistry and biology opens a new subject of chemical biology, extending new field for human to reveal the nature of life at molecule level. Molecular recognition and self-assembly are always the fundament of information storage, duplication and transferring in nature, and therefore based on this, the fabrication of specific supramolecular systems with target biological functions will be crucial important in revealing the nature and process of life. Based on our previous studies, three concerning fields are summarized in the present paper：（1） The mimic of glutathione peroxide （GPX） and the recognition between it and substrate; （2） Tissue regeneration material and bioactivated scaffold; （3） self-assembly and disassembly of virus-like particle （VLP）.

作者沈家骢吴玉清

机构地区吉林大学超分子结构与材料国家重点实验室

出处《化学进展》 SCIE CAS CSCD 北大核心 2007年第12期1839-1843,共5页 Progress in Chemistry

基金国家重点基础研究发展计划(973)项目(2007CB808000)资助

关键词化学生物学分子识别类病毒颗粒组装/解组装 chemical biology molecular recognition virus-like particles self-assembly/disassembly

分类号 Q50 [生物学—生物化学]

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