利用表面上的小分子控制细胞黏附

Using Small Molecules on Surfaces to Control Cell Adhesion

细胞黏附是重要的生理过程,多细胞生物体中大部分种类的细胞都依赖于在表面的黏附而进行其正常生理活动。细胞的黏附需要固定在表面的有机分子(例如蛋白质或多肽)作配体。我们利用表面上的小分子模拟蛋白质或多肽作为配体,通过与细胞膜上受体结合,促进细胞黏附到表面。聚乙二醇(PEG)可以抵抗细胞在表面的黏附,我们利用含有PEG的表面来调节细胞黏附。细胞表面的受体与胞外基质表面的配体结合是一个动态过程,在适宜时间和空间发生的时候,细胞就会产生运动和迁移,细胞的迁移也是重要的生理过程。本文主要介绍近年来利用小分子的表面化学和微纳米结构控制细胞在表面的黏附和迁移。

Cell surfaces to carry out molecules as ligands, adhesion is an important physiological process, most types of metazoic cells rely on adhesion to their functions. The adhesion of mammalian cells requires the presence of surface-immobilized in most cases, proteins or peptide mimics thereof, that bind to receptors on the cell membrane. The binding between these ligands and receptors promotes the adhesion of cells. Polyethyleneglycol （PEG） can resist cell adhesion. We use these small molecules to modulate cell adhesion on surfaces. Cell motility is a dynamic process in which the binding between extracellular ligands and receptors on cell membrane undergo regulation in appropriate time and space. This review introduces several newly developed tools using small molecules on surfaces and microfabrication to control cell adhesion and motility.