摘要
如何选择性地破坏癌细胞DNA链结构的药物,一直是研究的热点,可诱导核酸交联剂在增加药物靶标选择性方面有很多优点。利用氧化、还原或光诱导产生的DNA交联作用,在临床治疗中具有重要意义。本文就可诱导核酸交联剂的最新研究进展做了评述。
Selectively destroy the DNA of the tumor cells by induction has been arosed much attention for medicinal application. Inducible DNA cross-linking agents have provided a promising method for these researches. The selectivities of the targets induced by various methods, such as oxidation, reduction and light-induction to cross-link DNA, hold great importance on clinic therapy. The most recent advances on inducible DNA cross-linking agents are reviewed in this paper.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2007年第12期1999-2005,共7页
Progress in Chemistry
基金
国家自然科学基金(No.20672084)
国家杰出青年基金(No.20425206)
高等学校科技创新工程重大项目培育资金项目(No.706040)资助
关键词
DNA
交联
诱导
DNA
cross-linking
induction
