摘要
大量突变和错误折叠的蛋白质在细胞内聚集是神经退行性疾病产生的基础,研究发现一些小分子可以通过引起细胞自噬而降解细胞内聚集的突变蛋白,为治疗神经退行性疾病提供了新的方法。本文对神经退行性疾病的发病机理,细胞自噬的机理以及对神经退行性疾病的作用进行了综述。
Intracellular accumulation of altered and misfolded proteins is the basis of most neural degeneration diseases. A novel path for therapy of neural degeneration diseases is offered by the application of small molecule, which enhances the clearance of aggregate-prone proteins through inducing autophagy. In this review we introduce the pathogenesis of neural degeneration diseases, the mechanism of autophagy and the effect on neural degeneration diseases.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2007年第12期2012-2016,共5页
Progress in Chemistry
关键词
细胞自噬
神经退行性疾病
autophagy
neural degeneration diseases