AAISafeR起搏模式自身对照研究

A self-control study of AAISafeR pacing mode

目的分析患者置入具有AAISafeR功能的Symphony2450起搏器后,短期内心脏结构和功能改变的特点及其与心室起搏百分比之间的关系。方法共入选22例患者,采用随机、单盲、自身前后交叉对照原则,观察同一患者在不同起搏模式下(AAISafeR和DDD)左房内径(LAD)、左室舒张末径(LVEDV)、左室收缩末径(LVESV)及左室射血分数(LVEF)的变化。结果不同起搏模式分别观察3个月后,LAD缩小(38.5±5.7mmvs39.7±4.5mm,P<0.05),但LVEDV、LVESV及LVEF变化不大。与DDD模式相比,AAISafeR模式下心室起搏、感知百分比有显著性差异(分别为67.49%±13.09%,43.89%±12.28%vs45.23%±11.15%,64.88%±15.08%,P均<0.05)。结论AAISafeR模式可有效减少心室起搏的百分比,较高比例的心室起搏百分比短期内(3个月)可影响心腔结构的重塑,但尚未引起心室功能的改变。

Objective To analyse the relationship of cardiac structure and function with cumulative percent ventficular pacing （ Cum% VP） in patients implanted with Symphony 2450. Methods To observe the changes of left atrial diameter （ LAD）, left ventricular end-diastole diameter （ LVEDV ） , left ventricular end-systole diameter （ LVESV ） and left ventricular ejection fraction （LVEF）with different pacing modes （DDD, AAISafeR） in 22 patients in a single-blinded, randomized and self-control controlled principle. Result After 3-month following-up with different pacing modes separately, LAD was reduced （38.5 ± 5.7 mm vs 39.7±4.5 mm,P 〈 0.05 ）, but LVEDV, LVESV and LVEF did not change. Comparison with DDD mode, the Cum% VP in AAISafeR mode had a significant difference（67.49 % ±13.09% vs 45.23% ± 11.15 %, P 〈 0.05）. Conclusion The mode of AAISafeR could reduced the Cum% VP markedly.