黄龙肝脂消颗粒对高脂血症性脂肪肝小鼠肝组织血脂及病理学的影响

Effects of Huanglong Ganzhixiao Granule on Blood Lipid and Hepatic Histopathology in Mice with Fatty Liver due to Hyperglycemia

目的:观察黄龙肝脂消颗粒对脂肪肝小鼠的治疗作用。方法:以高脂乳剂复制小鼠脂肪肝模型,以东宝肝泰片为阳性对照,观测黄龙肝脂消颗粒对小鼠肝脏血脂及组织病理的影响。结果:黄龙肝脂消颗粒高、中剂量组能明显降低脂肪肝小鼠肝脏组织中总胆固醇(TC)、甘油三酯(TG)的含量(P<0.01或P<0.05);低剂量组能明显降低脂肪肝小鼠肝脏中甘油三酯(TG)的含量(P<0.01)。此外,黄龙肝脂消颗粒能使肝组织中脂变肝细胞数目明显减少,胞浆内脂滴数目减少或消失,无明显炎细胞坏死或浸润。结论:黄龙肝脂消颗粒具有降血脂及改善肝脂肪化变性的作用,对脂肪肝有良好的治疗作用。

Objective： To observe the therapeutic effects of Huanglong Ganzhixiao granule on mice with fatty liver. Methods： The models of mice with fatty liver were duplicated with high - fat emulsion. The effects of Huanglong Ganzhixiao granule on blood lipid and hepatic histopathology in mice were observed, using Dongbao C, anTai tablet as a positive control. Results： The contents of total cholesterol （TC） and triglyceride （TG） in liver tissue of mice with fatty liver were reduced remarkably in the high dose and mid - dose groups of Huanglong Gsnzhixiao granule（P 〈 0.01 or P 〈 0.05）, while the low dose group only had a significant decrease in the contents of TG（P 〈 0.01） .Furthermore, other phenomena were observed in the Huanglong Ganzhixiao granule groups, including pronounced reduction in the number of liver cells with fatty degeneration, significandy decreased or disappeared cytoplasmic lipid droplets and no significant necrosis or infiltration of inflammatory cells. Conclusions： Huanglong Ganzhixiao granule has good therapeutic action on fatty liver by reducing blood lipid and hepatic steatosis.