摘要
目的:建立那保胶囊(黄芪、当归、延胡索、白花蛇舌草、铁棒锤等)的质量标准。方法:采用TLC对处方中当归、延胡索及白花蛇舌草进行鉴别,对毒性药材铁棒锤进行限量检查,采用高效液相色谱-蒸发光散射检测器(HPLC-ELSD)法测定黄芪甲苷的含量。结果:TLC鉴别分离度好,专属性强;铁棒锤中乌头碱含量不超过规定;黄芪甲苷在1～10μg的范围内线性关系良好(r=0.9990),平均回收率为99.05(RSD=2.48,n=6)。结论:所建立的质量标准方法可靠、准确、专属性强,可有效控制那保胶囊的质量。
AIM ： To establish the quality standard for Nabao Capsule （Radix Astragali, Radix Angelicae sinensis, Rhizoma Corydalis, Herba Hedyotis, etc. ）. METHODS ： Radix Angelicae sinensis, Rhizoma Corydalis, Herba Hedyotic and Pendulous Monkshood Root in Nabao Capsule were identified by TLC. Astragaloside Ⅳ was determined by HPLC. RESULTS： The characteristic identification by TLC was distinct and highly specific, the quantitative evaluation of thymol had the linear range of 1-10 μg. The average recovery was 99.05% and RSD was 2.48%. CONCLUSION： The method is reliable, accurate and specific, and can be used for the quality control of Nabao Capsule.
出处
《中成药》
CAS
CSCD
北大核心
2007年第12期1783-1786,共4页
Chinese Traditional Patent Medicine
