5-羟色胺转运体基因第二内含子多态性与自杀未遂的关联分析

An analysis on the relationship between polymorphism of intron 2 in serotonin transporter gene and at-tempted suicide

目的探讨5-羟色胺转运体（5-HTT）基因第二内含子多态性（5-HTFVNTR）与自杀未遂的相关性。方法运用聚合酶链反应技术（PCR）检测71例自杀未遂患者（患者组）和80名健康对照者（对照组）5-HTTVNTR的三种基因型及等位基因分布频率。结果自杀未遂组第二内含子基因型及等位基因分布频率与正常对照组之间（基因型10／10：5 VS 7；基因型10／12：29 VS 31；基因型12／12：37 VS 42；等位基因10：39 VS 45；等位基因12：103 VS 115）差异无显著性（X^2=0．181，P=0．914；X^2=0．016，P=0．898）。结论汉族人群中5-HTT基因第二内含子多态性与自杀未遂没有明显相关性。

Objective To explore the association between attempted suicide and polymorphism of intron 2 in serotonin transporter （5-HTT）. Methods Using the technique of polymerase chain reaction （ PCR）, the variable number of tandem repeat polymorphism（VNTR） of intron 2 in serotonin transporter gene was determined in 71 patients with attempted suicide subjects and 80 control subjects. The allelie and genetypes distributions in two groups were compared. Results There were no significant differences in intron 2-VNTR genotype and allele fre- quency distributions between attempted suicide and healthy control subjects. Conclusion The results suggest that the polymorphism of intron 2 of 5-HTF gene should not associated with attempted suicide in the Hun nationality.