难治性抑郁症患者血小板五羟色胺水平分析

An analysis on the serotonin levels in the platelets of patients with treatment resistant depression

目的通过测定血小板五羟色胺（5-HT）水平，探讨难治性抑郁症患者的相关生化机制特点。方法采用一般情况问卷（自编）、汉密顿抑郁量表17项（HAMD17）、汉密顿焦虑量表（HAMA）评定难治性抑郁症患者的一般情况与焦虑抑郁情绪，测定患者外周血小板5-HT含量。结果共收集难治性抑郁症患者38例，血小板5-HT值为（99．9±118．5）ng／10^9，60例非难治性抑郁症患者为（242．8±174．4）ng／10^9，2组差异有显著性（P〈0.01）；难治性抑郁症患者血小板5-HT含量和本次病程长短、HAMD行为阻滞因子存在正相关关系。结论难治性抑郁症患者的血小板5-HT含量水平较低，与本次发作病程长短和行为阻滞症状之间存在一定的关系。

Objective By evaluate the serotonin levels in the platelet of patients with treatment resistant depression（TRD） so as to explore the related biochemical mechanism. Methods Patients suffering from treatment resistant depression were evaluated by the general state investigating scale （the items were made by our own）, Hamilton Depression Scale （HAMD） and Hamilton Anxiety scale（HAMA）. The platelet serotonin were measured by the methods of high-performance liquid chromatography （HPLC） and electrochemical detection. The serotonin levels in the platelets of the treatment resistant depressed patients were compared to the ones of the treat- ment responsible depressed patients. Results The serotonin levels in the platelets of TRD patients were significant lower than those of responsible depressed patients [（99.9±118.5 ）ng/10^9 vs （242.8±174.4）ng/10^9, P 〈 0.01 ] , and positively related to two factors ： current episode duration, retardation scores of HAMD. Conclusion The low platelet serotonin level may be one of the biochemical characters in patients with TRD. The current episode duration and the retardation symptoms may influence the level of platelet serotonin.