Rh新生儿溶血病的血清抗体分析

Study of serum anti with Rh hemolytic disease of the newborn

目的对20例Rh新生儿溶血病血清抗体回顾性分析。方法采用直接抗人球蛋白试验、游离抗体试验、放散试验检测ABO以外的抗体,采用微柱凝胶间接抗人球蛋白试验进行抗体鉴定。结果20例Rh溶血病患儿中由抗D引起的溶血病有11例,由抗-D和Rh其他系统抗体联合引起的有4例,共15例,占75%;由抗-E引起有3例,由抗-E和抗-c联合引起1例,占20%;由抗-C引起1例,占5%。20例患儿母亲都曾有生产或流产或输血史。结论为预防新生儿Rh溶血病的发生,尤其是对曾有过生产史、流产史或输血史的孕妇作产前夫妇Rh血型和孕妇Rh免疫性血清抗体筛查极有必要。

Objective To study of serum anti 20 patients with Rh hemolytic disease of the newborn. Methods ABO extracardiac antibody is detected with deploying straight Coombs＇test, liberation antibody, irradiation test, antibodies accredit with tester microcolumn gel coombs test. Results Of the 20 patients with Rh hemolytic disease, 11 patients were provoked by anti-D and 4 patients were by anti-D and other Rh system antibody,occupying 75% .3 patients were provoked by anti-E and 1 patient were provoked by anti-E and anti-e, occupying 20%. 1 patient were provoked by anti-C, occupying 5 %. And 20 patients mothers had already hayed childbearing or miscarriage or blood transfusion. Conclusion To prevent beforehand Rh hemolytic disease of the newborn, It is essential that Rh blood group of the couple are detected and gravida Rh system antibody are screened before gravida childbearing especially be; fore gravida childbearing who had already haved childbearing or miscarriage or blood transfusion.