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氨基糖苷类双功能修饰酶AAC(6′)-APH(2″)的研究进展 被引量：3

Research update of aminoglycoside bifunctional modifying enzyme AAC(6′)-APH(2″)
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作者 李聪然 游雪甫 蒋建东
机构地区 中国医学科学院中国协和医科大学医药生物技术研究所药理室
出处 《中国感染与化疗杂志》 CAS 2007年第6期468-471,共4页 Chinese Journal of Infection and Chemotherapy
基金 国家十五科技重大专项药代平台子课题(2003AA2Z347D) 国家自然科学基金课题(30472058 30672502) 北京市自然科学基金课题(7062044)
关键词 AAC(6′)-APH(2″) 氨基糖苷类 传播 抑制剂
分类号 R91 [医药卫生—药学]
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参考文献31

  • 1Schatz A, Bugie E, Waksman SA. Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. 1994[J]. Proc Soc Exp Biol Med, 2005, 437 : 3-6.
  • 2Azucena E, Mobashery S. Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition [J]. Drug Resist Updat, 2001, 4(2): 106-117.
  • 3Llano-Sotelo B, Azucena EF Jr, Kotra LP, et al. Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site [J]. Chem Biol, 2002, 9(4): 455-463.
  • 4Ferretti J J, Gilmore KS, Courvalin P. Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2'-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities [J]. J Bacteriol, 1986, 167(2): 631-638.
  • 5Le Goffic F. The resistance of S. aureus to aminoglycoside antibiotics and pristinamycins in France in 1976-1977[J]. Jpn J Antibiot, 1977, 30 (Suppl): 286-291.
  • 6Ubukata K, Yamashita N, Gotoh A, et al. Purification and characterization of aminoglycoside-modifying enzymes from Staphylococcus aureus and Staphylococcus epidermidis[J]. Antimicrob Agents Chemother, 1984, 25 (6): 754-759.
  • 7Rouch DA, Byrne ME, Kong YC, et al. The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis [J]. J Gen Microbiol, 1987, 133(11): 3039-3052.
  • 8Shaw KJ, Rather PN, Hare RS, et al. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes[J]. Microbiol Rev, 1993, 57 (1): 138-163.
  • 9Daigle DM, Hughes DW, Wright GD. Prodigious substrate specificity of AAC(6')-APH(2'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci[J].Chem Biol,1999, 6 (2): 99-110.
  • 10Boehr DD, Jenkins SI, Wright GD. The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2'. The role of Asp-99 as an active site base important for acetyl transfer[J]. J Biol Chem, 2003, 278 (15) : 12873-12880.

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中国感染与化疗杂志
2007年 第6期

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