新生儿缺氧缺血性脑病血浆ET和CGRP测定及临床意义

Clinical Significance of Determination of Changes of Plasma ET and CGRP Contents in Neonates with Hypoxic-Ischemic Encephalopathy

目的:探讨新生儿缺氧缺血性脑病患者血浆内皮素(ET)和降钙素基因相关肽(CGRP)水平的变化及临床意义。方法:应用放射免疫分析检测了符合诊断标准的观察组缺氧缺血性脑病新生儿68例,及对照组同期健康新生儿30例血浆中ET和CGRP水平,并做了比较。结果:观察组血浆ET水平显著的高于对照组,而CGRP水平显著的低于对照组。结论:新生儿缺氧缺血性脑病的发生发展与ET和CGRP水平的变化密切相关。

Objective To investigate the clinical significance of changes of plasma ET and CGRP levels in neonates with hypoxic - ischemic encephalopathy （HIE）. Methods Plasma ET and CGRP contents were determined with RIA in 68 neonates with hypoxic - ischemic encephalopathy and 30 controls. Results In neonates with HIE, the plasma ET levels were significantly higher than those in the controls （P 〈0.01）, while the plasma CGRP levels were significantly lower（P 〈0.01）. Conclusion Development of hypoxic - ischemic encephalopathy in newborn infants was closely related to the plasma ET and CGRP levels.