多囊卵巢综合征患者血清瘦素和胰岛素检测的临床意义

Clinical Significance of Changes of Serum Leptin and Insulin Levels in Patients with Polycystic Ovary Syndrome

目的:检测多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清瘦素(leptin)及胰岛素(insulin)含量,以探讨leptin与PCOS的关系。方法:采用放射免疫分析检测34例PCOS患者及30例健康对照组血清中的leptin和insulin浓度。结果:PCOS患者血清中的leptin及insulin含量均高于健康对照组,且有高度显著性差异(P<0.01);同时,PCOS患者中的肥胖组与非肥胖组相比二者也有高度显著性差异(P<0.01),肥胖组高于非肥胖组。结论:血清leptin和insulin与PCOS可能有较好的相关性,提示血清leptin含量可作为PCOS患者的一项辅助诊断指标。

Objective To explore the relationship between the serum leptin, insulin levels and development of polycystic ovary syndrome （PCOS）. Methods Serum leptin and insulin levels （with RIA） were determined in 34 patients with PCOS and 30 controis. Results The serum leptin and insulin levels in the 34 PCOS patients were significantly higher than those in controls （ P 〈 0. 01 ）, and those in obese patients （ n = 22） were significantly higher than those in non - obese ones （ n = 12） too （ P 〈 0.01 ）. Conclusion Changes of serum leptin and insulin levels were closely related to the development of PCOS and leptin might be used as a diagnostic indicator for PCOS.