急性脑梗死患者治疗前后血清VEGF、TGF-β_1水平的变化及其临床意义

Clinical Significance of Changes of Serum VEGF,TGF-β_1 Levels After Treatment in Patients with Acute Cerebral Infarction

目的:探讨了急性脑梗死患者治疗前后血清VEGF、TGF-β1水平的变化及临床意义。方法:应用酶联免疫法测定了33例急性脑梗死患者治疗前后血清VEGF、TGF-β1水平的变化,并与35名正常人作比较。结果:急性脑梗死患者在治疗前血清VEGF非常显著地高于正常人组(P<0.01),而TGF-β1水平则显著地低于正常人组(P<0.01),经治疗后两周则与正常人组比较无显著性差异(P>0.05)。结论:检测急性脑梗死患者血清VEGF、TGF-β1水平的变化对了解病情、指导临床实践均具有重要的临床价值。

Objective To explore the clinical significance of changes of serum VEGF, TGF - β1 levels after treatment in patients with acute cerebral infarction. Methods Serum VEGF, TGF - β1 levels were determined with ELISA in 33 patients with acute cerebral infarction both before and after treatment as well as in 35 controls. Results Before treatment, the serum VEGF levels were significantly higher than those in controls （ P 〈 0.01 ）, but the serum TGF - β1 levels were significantly lower （ P 〈 0.01 ）. After treatment for two weeks the levels in patients were not much different from those in controls （ P 〉 0.05 ）. Conclusion Serum VEGF, TGF - β1 levels were closely related to the diseases process of acute cerebral infarction and were of prognostic values.