水相催化加氢制备对氨基苯乙酸

Preparation of p-Aminophenylacetic Acid by Catalytic Hydrogenation in Water Phase

研究了以对硝基苯乙酸为原料，以Pd—C为催化剂，以去离子水为溶剂，液相催化加氢制备对氨基苯乙酸的还原反应，确定了最佳反应条件：反应温度60～80℃，反应压力0．5—1．0MPa，溶剂溶质比为100mL／0．2tmol，产品纯度98．27％，收率达90．3％。

The reduction of.p -nitrophenylacetic acid by liquid phase catalytic hydrogenation for preparation of p -aminophenylacetic acid is studied, with Pd -C as catalyst and industrial methanol as solvent. The optimal conditions are obtained as follows ： reaction temperature 6 0 -8 0 ℃ , reacton pressure 0. 5 - 1 . 0 MPa, solvent / reactant ratio 1 0 0 mL / 0. 2 mol . Under these conditions the purity of the product is 98.27%and the yield is 90.3%.