用胶原性关节炎模型探讨中药治疗类风湿性关节炎作用机制的研究进展

Advances of Mechanism on Traditional Chinese Medicine of Anti-rheumatoid Arthritis by Using Collagen-induced Arthritis

目的:了解中药治疗胶原性关节炎的研究进展及中药治疗类风湿性关节炎(RA)的作用机制。方法:检索中国学术期刊全文数据库1987-01/2007-01全部有关中药治疗胶原诱导性关节炎模型的作用效果的文献,并参考部分国外有关胶原性关节炎模型研究的文献。结果:中药治疗RA的作用机制比较复杂,可以通过多环节,多靶点的途径发挥疗效:抑制免疫反应,调节T细胞亚群,调整致炎或抑炎的细胞因子、酶蛋白、基因的表达水平及平衡。结论:与作用途径相对单一的西药相比,中药治疗RA具有广阔的前景,其作用机制有待于进一步研究。

Objective： To investigate the effect of traditional Chinese medicine on treating collagen-induced arthritis,so as to find out its mechanism. Methods： Review relevant article about the effect which traditional Chinese medicine treat collagen-induced arthritis from Chinese Academic periodical Full-text Database from January 1987 to January 2007. Meanwhile,review many English articles related to collagen-induced arthritis. Results： The mechanism that rheumatoid arthritis treated with traditional Chinese medicine is a complex process, which may have therapeutic effects through many ways and poly-target： inhibiting immune responses, adjusting T-cell subgroup, regulating the cytokine of promoting or restraining inflammatory and the balance of enzymes-proteins and the level of genes expression. Conclusion： Comparing with single western medicine treatment, traditional Chinese medicine is full of bright prospect in treating RA and the mechanism need to be futher studied.