摘要
目的:了解中药治疗胶原性关节炎的研究进展及中药治疗类风湿性关节炎(RA)的作用机制。方法:检索中国学术期刊全文数据库1987-01/2007-01全部有关中药治疗胶原诱导性关节炎模型的作用效果的文献,并参考部分国外有关胶原性关节炎模型研究的文献。结果:中药治疗RA的作用机制比较复杂,可以通过多环节,多靶点的途径发挥疗效:抑制免疫反应,调节T细胞亚群,调整致炎或抑炎的细胞因子、酶蛋白、基因的表达水平及平衡。结论:与作用途径相对单一的西药相比,中药治疗RA具有广阔的前景,其作用机制有待于进一步研究。
Objective: To investigate the effect of traditional Chinese medicine on treating collagen-induced arthritis,so as to find out its mechanism. Methods: Review relevant article about the effect which traditional Chinese medicine treat collagen-induced arthritis from Chinese Academic periodical Full-text Database from January 1987 to January 2007. Meanwhile,review many English articles related to collagen-induced arthritis. Results: The mechanism that rheumatoid arthritis treated with traditional Chinese medicine is a complex process, which may have therapeutic effects through many ways and poly-target: inhibiting immune responses, adjusting T-cell subgroup, regulating the cytokine of promoting or restraining inflammatory and the balance of enzymes-proteins and the level of genes expression. Conclusion: Comparing with single western medicine treatment, traditional Chinese medicine is full of bright prospect in treating RA and the mechanism need to be futher studied.
出处
《中国实验方剂学杂志》
CAS
2007年第12期62-65,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
类风湿性关节炎
胶原诱导性关节炎
作用机制
中药
细胞因子
rheumatoid arthritis ( RA )
collagen-induced arthritis ( CIA )
mechanism
traditional Chinese medicine
cytokine