期刊文献+

中晚期宫颈癌同步放化疗临床疗效观察 被引量:5

下载PDF
导出
摘要 目的:探讨同步放化疗对中晚期宫颈癌的近期临床疗效。方法:2000年6月至2002年6月,对51例放化疗同步组中晚期宫颈癌采用顺铂(DDP)40mg/m2第1~3天静脉点滴,5-氟脲嘧啶(5-Fu)1.0mr/m^2第1~5天静脉点滴,21~28天为1周期,共用2周期;同时采用”钴放疗机体外放疗,盆腔前后两野对穿照射,面积18×14cm,每野2Gy,组织量达46~50Gy,使用铱-192后装治疗机进行腔内照射,每次6~7Gy,每周1次,共照射5~6次,A点总量DT36~42Gy。单纯放疗组49例,放射治疗同上。两组均在放疗结束后评价疗效。结果:近期疗效,同步放化疗组CR72.6%。RR86.3%;单纯放疗组CR46.9%,RR67.3%。两组比较P〈0.0、P〈0.05,差异均有统计学意义。主要不良反应为消化道反应和骨髓抑制,以Ⅰ~Ⅱ度为主,无严重不良反应。结论:同步放化疗治疗中晚期宫颈癌,可提高近期疗效,改善生活质量,应做为中晚期宫颈癌的主要治疗手段。
出处 《包头医学院学报》 CAS 2007年第6期629-630,共2页 Journal of Baotou Medical College
  • 相关文献

参考文献2

二级参考文献41

  • 1[1]Delgado G, Bundy B, Zaino R, et al. Prospective surgicalpathological study of disease- free interval in patients with stage Ⅰ B squamous cell carcinoma of thr cervix: A Gynecologic Oncology Group study. Gynecol Oncol 1990, 38:352
  • 2[2]Sevin BU, Lu Y, Bloch BA, et al. Surgical defined prognostic parameters in patients with early cervical carcinoma: A multivariate survival tree analysis. Cancer, 1996, 78:1438
  • 3[3]Kinney WK, Alvarez RD, Reid GC, et al. Value of adjuvant whole- pelvis irradiation after Wertheim hysterectomy for earlystage squamous carcinoma of the cervix with pelvic nodal metastasis: A matched-control study. Gynecol Oncol, 1989, 34:258
  • 4[4]Stehman FB, Bundy BN, Thomas G, et al. Hydroxyurea versus mosonidazole with radiation in cervical carcinoma: Longterm follow - up of a Gynecologic Oncology Group trial. J Gin Oncol, 1993, 11:1523
  • 5[5]Thomas G, Dembo a, Fyles A, et al. A randomized trial of standard versus partially hyperfractionated radiation with or without concurrent 5 - fluorouracil in locally advanced cervical cancer. GynecolOncol, 1998, 69:137
  • 6[6]Thomas G, Dembo A, Beale F, et al. Concurrent radiation, mitomycin C and 5- fluorouracilnin poor prognosis carcinoma of cervix: Preliminary results of a phase Ⅰ~Ⅱ study. Int J Radiat Oncol Biol Phys, 1984, 10:1785
  • 7[7]Thomas G, Dembo A, Fyles A, et al. Concurrent chemoradiation in advanced cervical cancer. Gynecol Oncol, 1990, 38:446
  • 8[8]AlbertsDs, KronalR, Baker LH, et al. Phaes Ⅱ randomized trial of cisplatin chemotherapy regimens in the treatment of recurrent or metastatic squamous cell cancer of the cervix. A Southwest Oncology Group study. J Clin Oncol, 1987, 5:1791
  • 9[9]Omura GA, Blessing J, Vaccarello L, et al. A randomized trial of cisplatin versus cisplatin plus mitolactol versus cisplatin plus ifosfmide in advanced squamous carcinoma of the cervix: A Gynecologic Oncology Group study. J Glin Oncol, 1997, 15:165
  • 10[10]Vokes EE, Weichselbaum RR. Concomitant chemotherapy: rational and clinical experience in patients with solid tumors. J Clin Oncol, 1999, 8:911

共引文献78

同被引文献10

引证文献5

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部