生存素和血管内皮生长因子在宫颈癌组织中的表达及其意义

Expression and significance of survivin and vascular endothelial growth factor in cervical cancer

目的 探讨生存素（survivin）与血管内皮生长因子（VEGF）在宫颈癌组织中的表达及其意义。方法 采用免疫组织化学方法检测生存素和VEGF在46例宫颈癌组织及20例正常宫颈组织中的表达。结果生存素在宫颈癌组织和正常宫颈组织中的表达率分别为63．0％（29例）和10．0％（2例），差异有统计学意义（χ^2=15．75，P〈0．01）。VEGF在宫颈癌组织和正常宫颈组织中的表达率分别为73．9％（34例）和15．0％（3例），差异有统计学意义（χ^2=29．98，P〈0．01）。结论生存素和VEGF在宫颈癌组织中的异常表达可能对宫颈癌的发生起着重要作用。

Objective To investigate tile expression and significance of gene survivin and va^cular endothelial growth factor （VEGF） in cervical cancer. Method Immunohistoc.hemical method was apphed to examine the expression of survivin and VEGF,in 20 normal and 46 cervical cancer tissues. Results Survivin was detected in 29 of 46 （63.0%） cervical cancer tissues, but 10.0% in normal cervix tissues,the expression of survivin in the two groups was significantly different （χ^2= 15.75 ,P 〈 0.01 ）. VEGF was detected in 34 of 46 （73.9%） cervical cancer tissues, but 15.0% in normal cervix tissues, the expression of VEGF in the two groups was significantly different （χ^2= 29.98 ,P〈 0.01 ）. Conclusion Survivin and VEGF play an important role in the development of cervical cancer tissues.