孤立性纤维性肿瘤3例临床病理分析

Analysis of Clinicopathological features in 3 cases with solitary fibrous tumor

目的:探讨孤立性纤维性肿瘤(Solitary fibrous tumor,SFT)的临床病理特征、免疫表型及诊断与鉴别诊断。方法:对3例孤立性纤维性肿瘤进行临床和病理学观察及免疫组化标记,并复习有关文献。结果:3例SFT肿瘤皆较大,肿瘤由梭形纤维母细胞样细胞及少数卵圆形细胞构成,呈束状交错排列及片状分布,部分区域可成血管瘤样结构,间质内有较多玻璃样变的胶原纤维。例2与例3呈良性表现;例1发生于腹腔,肿瘤细胞核分裂数>4个/HPF,并见浸润性生长,诊断为侵袭性SFT。免疫组化:CD34、bcl-2、Vim呈阳性。结论:SFT是一类较少见的梭形细胞肿瘤,发生部位和形态多样,肿瘤大多为良性,极少部分为侵袭性SFT。

Objective： To study the characteristics of clinicopathology and immunohistochemistry stain and diagnosis with its differential diagnosis in solitary fibrous tumor （SFT）. Methods. Light microscopy and immunohistochemical stains were performed in 3 cases with solitary fibrous tumor. Their clinical information and some relative literatures were reviewed. Results. The tumor was large in 3 cases of SFT. The tumor composed of spindle fibroblast-like cells and minority orbicular-ovate cells. The spindle cells arranged in short intersecting fascicles or storiform arrays. The part areas showed hemangioma-like structure, and more collagen fiber. The cases 2, 3 were benign tumors. Cases 1 occurred in abdominal cavity. Mitoses index was high （〉4 mitoses per 10 high-power fields） with infiltrative growth pattern. The case was diagnosed invasion SFT. Expression of CD34, bcl-2 and Vim were detected in all cases. Conclusion. SFT is a rare spindle cell tumor. There are located at more organs and tissues and histological diversity. The majority tumor is benign SFT, only a few cases are invasive SFT.