5’-单磷酸腺苷在水和乙醇/水体系中的溶解度模型

Crystallization thermodynamic of adenosine 5'-monophosphate in water and ethanol

以固-液平衡理论溶解度模型、适用于非理想体系的λh方程为理论基础,结合本实验结晶条件,采用静态法测定了5’-单磷酸核苷(5’-AMP)在纯水以及不同配比乙醇/水体系中的溶解度,建立了5’-AMP水和乙醇/水体系的结晶热力学模型。显示该体系属于缔合引起的非理想溶液,并计算水及乙醇/水体系的溶解热和结晶热,为5’-单磷酸腺苷的工业结晶生产提供了热力学数据。

Data of the solubility of Adenosine 5 ＇ -monophosphate （5 ＇ -AMP） in water , and in aqueous ethanol is essential for solventing-out crystallization studies. The solubilities for the binary system 5 ＇ -AMP ＋ H2O solution and ternary system 5 ＇ -AMP ＋ H2O ＋ ethanol solution were determined in the temperature ranges 293 - 323 K over the volume fraction ethanol ranges of 0 - 2.0. The solubility data were used for modeling based on the Apelblat equation, the solid-liquid equilibrium model and the Ah equation. The Crystallization thermodynamic model and the expression of the relationship between the model parameters and the ratio of solventr, the dissolution heat and the crystallization heat of 5 ＇-AMP in water/ethanol have been estimated with the experimental solubility data. This study aims at providing the thermodynamic basis in the crystallizing process.