18^F-氟脱氧葡萄糖PET监测实体瘤放化疗疗效的应用进展

The development of monitoring chemotherapy and radiotherapy of solid tumor by 18^F- fluorodeoxyglucose PET

利用18^F-氟脱氧葡萄糖（18^F—FDG）PET监测肿瘤放疗或化疗的疗效以及区分残余或复发病灶已广泛用于临床。18^F-FDG PET定量分析肿瘤在治疗开始时的变化可以预测肿瘤对治疗的反应性及患者的预后，并可根据肿瘤的反应性调整治疗方案。利用18^F-FDG PET早期预测肿瘤对放、化疗的反应性，在个体化治疗方案的制定、减少无效治疗所带来的副作用等方面有着巨大的潜能。

18^F-fluorodeoxyglucose （18^F-FDG） PET imaging monitoring tumor response in patients undergoing ehemo-and radiotherapy and differentiation residual or recurrent viable tumor and therapy-induced fibrosis or scar tissue has been documented for various solid tumors. Furthermore, there are now several reporis suggesting that quantitative assessment of therapy-induced changes in tumor 18^F-FDG uptake may allow prediction of tumor response and patient outcome very early in the course of therapy. In nonresponding patients, trcatnlent may be adjusted according to the individual chemo-and radiosensitivity of the tumor tissue. Early prediction of tumor response to ehenlotherapy and radiotherapy by 18^F-FDG PET has enormous potential to ＂personalize＂ treatment and to reduce the side-effects and costs of ineffective therapy.