辐射诱导的适应性效应及其分子机制

Radioadaptive response and its molecular mechanism

辐射适应性效应是一种生物防御机制，是指低剂量辐射可以增强细胞对随后高剂量照射的抵抗能力，从而降低高辐射引起的各种损伤。目前为止，RAR的分子机制还不清楚，研究主要涉及DNA损伤修复、细胞周期调控、细胞对抗氧化应激系统以及应激反应蛋白，参与细胞信号传递的分子主要包括蛋白激酶C、有丝分裂原激活蛋白激酶、p53蛋白、共济失调性毛细血管扩张突变基因及DNA依赖性蛋白激酶。

Radioadaptive response is a biological defense of which low dose ionizing radiation induces cellular resistance to the genotoxic effects of subsequent challenge irradiation. However, so for molecular mechanism of radioadaptive response remains obscure. Research is mainly involved in activation of the intracellular repair system, cell cycle regulation system, antioxidative stress system and stress-response protein. Signaling factors involved in cell response to radiation include protein kinase C, mitogen-activated protein kinase, p53 tumor suppressor protein, ataxia-telansiectasia mutated, and DNA-dependent protein kinase.