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RNA干涉治疗脑胶质瘤的研究进展

Research progress on treatment of glioma with RNA interference
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摘要 RNA干涉（RNAi）是由双链RNA引发序列特异性的转录后基因沉默。RNA干涉（RNAi）技术的出现为胶质瘤基因治疗的研究提供了新的策略。在研究过程中，不断有新的可能用于RNAi治疗脑胶质瘤的靶标基因被发现，其治疗脑胶质瘤作用主要通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、导致肿瘤细胞周期阻滞或增加肿瘤细胞化疗敏感性的机制来实现。 RNA interference （RNAi） is a post-transcriptional gene silencing induced by introduction of double-stranded RNA （dsRNA）. The emerging of RNAi provided a new method for glioma gene therapy. During the research, many new potential genes are continually finding out. And the glioma-treating mechanism include inhibiting cell proliferation, inducing cell apoptosis, blocking cell eyele and enhancing cell sensitivity of chemical.
作者 李峰生 陈肖华
机构地区 军事医学科学院放射与辐射医学研究所急性放射病损伤治疗研究室
出处 《国际放射医学核医学杂志》 2007年第5期300-302,共3页 International Journal of Radiation Medicine and Nuclear Medicine
基金 国家自然科学基金资助项目（30770640）
关键词 脑胶质瘤 细胞增殖 细胞凋亡 细胞周期 辐射耐受性 RNA干涉 Glioma Cell proliferation Cell apoptosis Cell cycle Radiosensitvity RNA interference
分类号 R73 [医药卫生—肿瘤]
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参考文献13

  • 1Falchetti ML, Fiorenzo P, Mongiardi MP, et al. Telomerase inhibition impairs tumor growth in glioblastoma xenografts. Neurol Res, 2006, 28(5): 532-537.
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二级参考文献10

  • 1张敏,张新,白春学,陈杰,MinQ.Wei.RNA干扰技术抑制A549细胞表皮生长因子受体表达的研究[J].中华肿瘤杂志,2004,26(12):713-717. 被引量：11
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  • 10杨晓葵,邢辉,高庆蕾,王薇,邬素芳,卢运萍,王世宣,马丁.mdr-1特异性核酶逆转卵巢癌的多药耐药[J].中华肿瘤杂志,2003,25(5):425-428. 被引量：10

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国际放射医学核医学杂志
2007年 第5期

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