P-选择素在支气管肺癌中的表达及其与肿瘤转移关系的研究

Study on the Expression of P-selectin in Lung Cancer and Their Correlation with Metastasis of Lung Cancer

目的研究P-选择素在支气管肺癌中的表达及其与肿瘤转移的关系。方法本文用免疫组化技术对20例癌旁肺组织、76例肺癌组织中P-选择素进行了检测。结果(1)P-选择素与肺癌组织学类型无关。(2)P-选择素在癌旁组织中不表达。(3)P-选择素与肺癌组织学分级无关。(4)P-选择素在I、Ⅱ、Ⅲ、Ⅳ期肺癌中阳性表达率分别为23·81%(5/21)、35·29%(6/17)、71·43%(15/21)、82·35%(14/17),其中I、II期表达率显著低于Ⅲ、Ⅳ期(P<0·05)。(5)在肺癌淋巴结转移组和无转移组P-选择素表达率分别为62·00%(31/50)、34·62%(9/26),两组之间有显著性差异(P<0·05)。(6)P-选择素在肿瘤间质血管内皮的阳性表达主要位于微动脉、微静脉、小动脉和小静脉,毛细血管未见其表达。结论P-选择素高表达提示高浸润转移风险。

Objective To discuss the P-selectin expression in lung cancer and the relation between P-selectin with metastasis of lung cancer. Methods Using immunohistochemical technique, we examined the expression of P-selectin in 20 paracancerous tissues and 76 lung cancer tissues. Results The results were as following. （1） The expression of P-selectin had no correlation with histological subtypes. （2） P-selectin was not expressed in paracancerous tissues. （3）The expression of P-selectin no correlation with histological grade. （4）In staging Ⅰ , staging Ⅱ , staging Ⅲ and staging Ⅳ cancer tissues, positive rates of P-selectin were 23.81% （5/21）, 35.29% （6/17）, 71.43% （15/21） and 82. 35% （14/17）, respectively. Among these groups,the expression rate in staging Ⅰ or staging Ⅱ was significantly higher than that in staging Ⅲ of staging Ⅳ （P〈0.05）. （5）The expression rates of P-selectin were 62.00% （31/50） and 34.62%（9/26） respectively in tumors with and without lymph node metastasis,showing significant difference between them. （6） P-selectin was mainly between the endothelial cells of arterioles, venules, small arteries and small veins,and capillaries were unlabelled. Conclusion The high expression of P-selectin indicated the risk of invasion and metastasis of lung cancer.