血管内皮祖细胞与调控性细胞因子

Vascular endothelial progenitor cells and regulatory cytokines

血管内皮祖细胞是一群起源于骨髓，具有与来源于胚胎血岛细胞有着相似特征的单核细胞群，作为内皮细胞的前体细胞，是血管组织工程的良好种子细胞。研究对内皮祖细胞的动员、增殖和分化有着调控作用的多种细胞因子（如GM-CSF、G-CSF、VEGF、EPO等），对揭示生理和病理状态下血管新生和修复的机制有着重要意义。本文就内皮祖细胞与对其有着调控作用的细胞因子的关系作一综述。

Vascular endothelial progenitor cells is a subtype of monocular cells that derived from marrow. As a progenitor cell of endothelial cell, it is a good seed cell in vascular tissue engineering. Studing on the cytokines that have the ability to regulate the mobilization, proliferation, differentiation of EPC （GM-CSF. G- CSF.VEGF and EPO） make sense to the research on angiogenesis. In this review,the relationship of EPC and the cytokines that can regulate it were summarized.