卵母细胞成熟过程MPF的调控和MPF的作用底物

Mechanism underlying regualtion and role of maturation promoting factor during oocyte maturation

下载PDF

导出

摘要系统综述卵母细胞成熟过程中成熟促进因子的调控及其作用底物。研究表明,卵母细胞成熟过程中,成熟促进因子的活性受Cdc25、Myt1和Wee1蛋白以及泛素信号途径的调控,而成熟促进因子本身又可作用于下游的信号分子,如Aurora A蛋白、核纤层蛋白和组蛋白等,来发挥其在成熟过程中的中心调控作用。 This review covers the regulation of maturation promoting factor and its role during oocyte maturation. Upstream signal molecule such as Cdc25, Mytl and Weel protein, as well as ubiquitin-dependent signaling system is required for regulation of MPF activity, while MPF plays a central role during maturaion process, regulating the activity of many downstreem factors, including Aurora A, lamine and histone protein and so on.

作者夏蕾张岭吴坤

机构地区哈尔滨医科大学附属第一医院生殖医学中心哈尔滨医科大学公共卫生学院营养与食品卫生学教研室

出处《疾病控制杂志》 CAS 2007年第6期614-617,共4页 Chinese Journal of Disease Control and Prevention

关键词卵母细胞减数分裂成熟促进因子 Oocyte Meiosis Maturation promoting factor

分类号 Q253 [生物学—细胞生物学]

引文网络
相关文献

参考文献20

1Kuroda T, Naito K, Sugiura K, et al. Analysis of the roles of cyclin B1 and cyclin B2 in porcine oocyte maturation by inhibiting synthesis with antisense RNA injection [J]. Biol Reprod, 2004, 70(1) :154-159.
2Margolis SS, Walsh S, Weiser DC, et al. PP1 control of M phase entry exerted through 14-3-3-regulated Cdc 25 dephosphorylation [J]. EMBO J, 2003,22(21):5734-5745.
3Qian YW, Erikson E, Taieb FE, et al. The polo-like kinase Plxl is required for activation of the phosphatase Cde25C and eyelin B-Cde2 in Xenopus oocytes [J]. Mol Biol Cell, 2001,12(6) : 1791- 1799.
4Karaiskou A, Jessus C, Brassac T, et al. Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification [J]. J Cell Sci, 1999,112(Pt 21) :3747- 3756.
5Hutchins JR, Dikovskaya D, Clarke PR. Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca( 2 + )/calmodulin-dependent protein [corrected] kinase Ⅱ [J]. Mol Biol Cell, 2003,14(10) : 4003-4014.
6Duckworth BC, Weaver JS, Ruderman JV. G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A [J]. Proc Natl Acad Sci USA, 2002,99(26):16794-16799.
7Iwabuchi M, Ohsumi K, Yamamoto TM, Sawada W, Kishimoto T. Residual Cdc2 activity remaining at meiosis Ⅰ exit is essential for meiotic M-M transition in Xenopus oocyte extracts [ J ]. EMBO J, 2000,19(17) :4513-4523.
8Nakajo N, Yoshitome S, lwashita J, et al. Absence of Weel ensures the meiotic cell cycle in Xenopus oocytes [J]. Genes Dev, 2000,14(3) :328-338.
9Han SJ, Chen R, Paronetto MP, et al. WeelB is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse [J]. Curr Biol, 2005,15(18) :1670-1676.
10Yamada A, Dully B, Perry JA, et al. DNA replication checkpoint control of Weel stability by vertebrate Hsl7 [J]. J Cell Biol, 2004,167 (5) : 841-849.

1白汝岚,孙燕,袁小丽,张家骅.MPF与MAPK在生殖细胞减数分裂中相互作用研究进展[J].动物医学进展,2007,28(2):55-57.
2张艳馥,沙伟.成熟促进因子与细胞周期调控[J].生物学教学,2007,32(11):8-9.
3陈红清.成熟促进因子(MPF)的生物学意义[J].生命的化学,1990,10(5):15-17.
4张美佳,王新庄,钱菊汾.成熟促进因子与细胞核移植[J].动物医学进展,1997,18(1):14-16.
5张彦明,张涌.成熟促进因子及其对卵母细胞成熟分裂的调控[J].动物医学进展,2000,21(1):31-35.
6肖文伍,傅新巧,张苏明.动物克隆核再程序化有关机理的研究进展[J].动物学杂志,2003,38(3):100-104. 被引量：4
7柳淑芳,杜立新,王继英.哺乳动物卵母细胞发育机理的研究进展[J].黄牛杂志,2001,27(4):43-45. 被引量：4
8征曰良,宋杰,仲跻峰.哺乳动物细胞核移植的研究进展[J].生物学通报,2002,37(3):5-7. 被引量：3
9桂建芳.卵母细胞在细胞周期调控研究中的贡献[J].中国科学基金,1996,10(3):173-178. 被引量：6
10佟超,范衡宇,李满玉,陈大元,孙青原.Polo like激酶在细胞分裂中的功能研究进展[J].生理科学进展,2002,33(1):45-47. 被引量：1

疾病控制杂志

2007年第6期

浏览历史

内容加载中请稍等...

卵母细胞成熟过程MPF的调控和MPF的作用底物

参考文献20

相关作者

相关机构

相关主题

浏览历史