乳腺癌中ER、PR和C-erbB-2的表达及与淋巴结转移的关系

Correlation Between Expression of ER,PR and C-erbB-2 in Breast Cancer and Metastasis of Axillary Lymph Nodes

目的探讨乳腺癌中雌激素受体(ER)、孕激素受体(PR)、C-erbB-2癌基因表达及其与腋窝淋巴结转移的关系。方法采用常规免疫组化SP法检测182例乳腺癌组织中ER、PR、C-erbB-2的表达。结果①ER、PR、C-erbB-2的阳性率分别为42.9%(78/182)、53.8%(98/182)、50.5%(92/182)。②C-erbB-2在ER、PR均阳性组的表达低于二者均阴性组的表达(P<0.05);淋巴结转移组中C-erbB-2的表达率高于淋巴结未转移组(P<0.05)。③ER的表达与PR的表达呈显著正相关,ER、PR的表达与患者的年龄、肿瘤大小、病理类型无关。结论ER、PR和C-erbB-2与乳腺癌的发生发展有关,ER、PR及C-erbB-2的测定是判断乳腺癌预后的重要指标,而且可以为临床制定乳腺癌的综合治疗方案提供重要依据。

Objective To explore the correlation of axillary lymph nodes metastases with the expression of ER,PR and C-erbB-2. Methods We used immunohistochemical method to detect the expression of ER, PR and C-erbB-2 in 182 cases of breast cancer. Results （1）The positive rates of expression of ER, PR and C-erbB-2 in breast cancers were 42. 9% ,53.8% ,50.5% respectively. （2）The positive rate of expression of C-erbB-2 in the positive group with the expression of ER,PR was lower than that in the negative group （P 〈 0. 05）. The positive rate of expression of C-erbB-2 in the group with the lymph node metastasis was higher than that in non-lymph node metastasis group （ P 〈 0. 05 ）. （3）ER expression had a positive correlation with PR expression. No significant association of expression ER, PR with age, tumor diameter and histological types was noted （P 〉 0. 05）. Conclusion ER, PR and C-erbB-2 are concerned with the development of breast cancer. Testing ER, PR and C-erbB-2 expression is of great significance to the formulation of therapeutic scheme.