邯郸市乙肝病毒宫内感染现状的研究

Study on Intrauterine Infection by Hepatitis B Virus in Handan City

目的探讨邯郸市孕妇乙肝病毒感染状况,HBsAg阳性孕妇孕期母婴阻断情况及其新生儿HBV宫内感染率。方法对5 280例孕妇进行HBsAg的检测,对HBsAg阳性孕妇孕期阻断措施的实施情况进行调查并对其新生儿进行静脉血HBsAg检测。结果5 280例孕妇中共检出HBsAg阳性孕妇366例,其中143例曾于妊娠最后3个月注射HB IG,应用HB IG的孕妇其新生儿宫内感染率与未应用者无显著性差异。结论邯郸市孕妇HBsAg携带率正在不断下降,孕期应用HB IG的HBsAg阳性孕妇比例逐年增多,然而孕期应用HB IG对控制HBV宫内感染未见成效。

Objective To study hepatitis B virus （HBV） status in pregnant women of Handan city, protective status of them and intrauterine fetal infective rate. Methods We detected 5280 pregnant women for HBsAg by ELISA, investigated protective status of the HBsAg-positive pregnant women and detected HBsAg and HBV DNA in newborns of theirs. Results 366 pregnant women were detected HBV by ELISA, 143 were injected HBIG three month before delivery. There was no significant difference between intrauterine fetal infective rate of protective HBsAg-positive pregnant women and no-protective ones. Conclusion HBV infection rate of pregnant women of our city is decreasing, protective injection rate is increasing, but injecting HBIG is ineffective to interruption of maternal-infantile transmission.