X射线交叉互补修复基因1多态性与食管癌易感性关系的Meta分析

Meta-analysis of X-ray Repair Cross Complementing Gene 1 Polymorphisms and Esophageal Cancer Risk

目的：探讨X射线交叉互补修复基因1（XRCC1）ARg194Trp与Arg399Gln多态性与食管癌（EC）易感性的关系。方法：检索CBMdisc、CMCC、CNKI、Pubmed、ScieneeDirect、Springer及EMCC等数据库，获得有关XRCC1多态性与EC易感性关系的病例对照研究并进行Meta分析，以病例组及对照组XRCC1 194Trp及399Gln等位基因分布的比值比（OR）为效应指标，应用Meta分析软件RevMan4．3对各研究原始数据进行统计处理及异质性检验，计算合并OR值及95％可信区间（CI）。结果：按照纳入标准。最终进入系统评价的文献病例．对照研究共有8篇，其中EC1452例，对照2449例。Meta分析结果显示，携带194Trp／Trp突变纯合子的个体发生EC的风险要高于对照组（合并0R=1．54；95％CI：1．15～2．05）。而其它3种基因型与EC之间无显著相关性。结论：XRCC1 Arg194Trp多态性与EC易感性之间存在相关，即携带PvuⅡ识别的突变型基因纯合子194Trp／Trp的个体发生EC的危险性较高。

Objective： To investigate the effect of X-ray repair cross complementing gene 1 （XRCC 1）genetic polymorphisms at codon 194 and codon 399 on esophageal cancer（EC）risk. Methods： The literature searched in CBMdisc, CMCC, CNKI, Pubmed, ScienceDirect, Springer and EMCC was carried out to find relevant papers, and the unpublished data were also collected. Odds ratios of XRCC1 194Trp, 399Gln allele distributions in the EC group and healthy control group were calculated. The meta-analysis was applied with RevMan 4.3 software for heterogeneity test and pooled OR calculation. Results： Of the case-control studies selected for this meta-analysis, a total of 1 452 EC cases and 2 449 controls were included. The pooled OR of XRCC1 genotype 194 Trp/Trp vs 194 Arg/Arg was 1.54（95%CI： 1.15- 2.05）. However, the distributions of the other 3 genotypes were no significantly different between two groups. Conclusion： The XRCC1 194 Trp/Trp genotype may contribute to the risk of esophageal cancer.