更年期妇女睡眠质量与血清雌二醇及催乳激素的相关性

The relativity between sleep quality in climacteric women and serum estradiol and prolactin

目的：探讨更年期妇女睡眠质量与血清雌二醇（E2）、催乳激素（PRL）的相关性。方法：采用匹兹堡睡眠质量指数问卷（PSQI）对吉林大学第二医院妇女保健门诊40～55周岁的更年期妇女进行睡眠质量评价；采用病例对照的方法，应用放射免疫测定法对更年期妇女睡眠质量差组（Ⅰ组）、更年期妇女睡眠质量正常组（Ⅱ组）和生育年龄正常对照组（Ⅲ组）妇女各30例进行血清E2、PRL水平测定。结果：Ⅰ组血清E2水平低于Ⅱ组和Ⅲ组妇女，且差异有显著性；血清PRL水平Ⅰ组和Ⅱ组低于Ⅲ组，均存在显著性差异；Ⅰ组与Ⅱ组间血清PRL水平没有显著性差异；更年期组血清PRL水平与E2水平无相关性。结论：更年期妇女睡眠质量差与血清E2水平降低有关，与更年期妇女血清PRL水平无关。

Objective： To study the relationship between climacteric women＇s levels of estradiol and prolactin in serum and their sleep quality. Methods： This study was performed in randomly chosen climacteric women aged between 40 - 55 years old in this outpatients, evaluated sleep quality by PSQI （the Pittsburgh sleep quality index） and used the case -control method. All quizzes were divided into three groups （ including 30 persons in every group） ： poor sleep quality climacteric women group （ group Ⅰ ）, normal sleep quality climacteric women group （ group Ⅱ ） and normal sleep quality childbearing women group （ group Ⅲ ） . The serum E2 （ 17beta - estradiol） and. prolactin levels were detected by RIA （radioimmunoassay） . Results： The levels of serum E2 in climacteric case group （ group Ⅰ ） was lower than that in two control groups （ group Ⅱ and group Ⅲ ）, and the distinctions were statistically significant. Poor climacteric women＇s sleep quality was not relevant with serum prolactin. There was no significant distinction in serum prolatin between group Ⅰ and group Ⅱ. The level of serum prolactin was not relative to serum E2 in two climacteric groups. Conclusion： The climacteric women＇s poor sleep quality correlates with their lower level of serum E2, but it is not relative to serum prolaetin.