液基细胞学应用于妇女生殖健康检查的研究

Study on women reproductive health examination with liquid-based cytologic test

目的：评价液基细胞学（Autocyte PREP test，LCT）和Bethesda系统（TBS）在妇女生殖健康检查中的应用价值。方法：对2005年10月～2006年9月在深圳市罗湖区计划生育服务中心行生殖健康检查的妇女，1380例（A组）接受LCT薄片法检查和TBS细胞学分类诊断及5796例（B组）妇女接受传统巴氏涂片法检查的资料进行回顾性分析。并对TCT薄片法发现异常的110例和传统巴氏涂片法检查发现ⅡB级以上的52例患者进行阴道镜病理检查。结果：A组的异常细胞检出率为12．68％，而B组仅为2．38％，两组结果差异具有显著性（P〈0．01）。LCT薄片法与病理诊断的阳性符合率为51．82％，显著高于传统巴氏涂片法（9．62％），P〈0．01。结论：LCT薄片法检出不典型鳞状细胞（ASCUS）以上病变阳性率明显优于传统巴氏涂片法，提倡在妇女的生殖健康检查中推广应用。

Objective. To evaluate the clinical value of liquid - based （LB） technologies （LCT） for women reproductive health examination. Methods： 1 380 cases examined by LCT and TBS, 5 796 cases with traditional cervical cells were analysed by retrospective study, all cases in Luohu Family Planning Service Station from October 2005 to September 2006 for women reproductive health examination, 110 abnormal eases with LCT and 52 eases with traditional smears above Ⅱ B were examined with colposcope. Results： The above - ASCUS pathological changes identified by LCT were 12. 68% , but traditional smears were only 2. 38% respectively. There was obvious difference between them （ P 〈 0. 01 ） . The positive coincidence rate between LCT and pathological examination was 51.82%, higher than that of traditional smears （9. 62%, P 〈0. 01 ） . Conclusion： It is useful method of LCT methods on women reproductive health examination, because of the LCT methods have apparent dominance in detecting above - ASCUS pathological changes than traditional smears.