弥漫性泛细支气管炎和慢性鼻窦炎的相关性研究进展

Progress of study on correlation between diffuse panbronchiolitis and chronic sinusitis

弥漫性泛细支气管炎（DPB）是一种呼吸性细支气管区域的慢性炎症性疾病，主要发病于东亚地区，多合并或既往有慢性鼻窦炎，属于鼻窦支气管综合征（SBS）的一种，遗传可能是DPB发病及其与慢性鼻窦炎有相关性的基础，其中最引人注目的是有关人类白细胞抗原（HLA）的研究，该文就DPB与HLA及慢性鼻窦炎的相关性作一综述。

Diffuse panbronchiolitis（DPB） ,a sinobronchial syndrome,is a chronic inflammatory disease characterized by chronic sinopulmonary inflammation in the nasal sinuses and, more frequently, in the respiratory bronchioles of both lungs. The incidence of DPB is primarily confined to individuals of east Asian ancestry. So genetic factor may play an important part in the pathogenesis of DPB and associate DPB with chronic sinusitis. Study on human leukocyte antigen（HLA） is the most spectacular in the field. This article summarizes the progress of study on correlation between DPB and chronic sinusitis.