参莲颗粒抗突变和抑瘤作用研究

Anti-tumor and Anti-mutation Effects of Shenlian Granules

目的:研究参莲颗粒的抗突变和抑瘤作用。方法:以小鼠骨髓细胞微核实验和睾丸染色体畸变实验观察参莲颗粒的抗突变作用;并观察参莲颗粒对S180和H22移植性肿瘤的抑制作用。结果:参莲颗粒对环磷酰胺诱发的小鼠骨髓细胞微核发生和丝裂霉素诱发的小鼠睾丸细胞染色体畸变均有显著的抑制效果;对S180和H22移植性肿瘤的生长有显著的抑制作用。结论:参莲颗粒对体细胞和生殖细胞的DNA损伤均有保护作用,对小鼠移植性肿瘤有较好的抑制作用。

OBJECTIVE： To study the anti tumor and anti mutation effects of Shenlian granules. METHODS： The anti- mutation effect of Shenlian granules was tested by marrow cell micronucleus test and didymus chromosomal aberration test in mice, and the inhibitory effect of which on S180 and H22 grafting tumor was invesgated as well. RESULTS： Shenlian granules showed significant inhibitory effect on mutation of marrow cell micronucleus caused by cyclophosphamide and aber ration of didymus chromosomal cell of mice caused by mitomycin as well as grafting tumor growth of S180 and H22. CONCLUSION： Shenlian granules can prevent DNA of both body cells and germ cells from damage but also inhibit grafting tumor growth in mice.