金刚藤分散片抗炎镇痛作用的药效学研究

Pharmacodynamic Study on the Antiinflammatory and Analgesic Effects of Jingangteng Dispersible Tablets

目的:研究金刚藤分散片(JDT)的抗炎镇痛作用。方法:采用小鼠耳廓肿胀模型、大鼠足跖肿胀模型和大鼠棉球肉芽肿模型来进行JDT的抗炎作用研究;采用小鼠扭体反应实验来进行JDT的镇痛作用研究;同时与阳性对照药金刚藤胶囊(JC)进行比较。结果:JDT对二甲苯所致小鼠耳廓肿胀、蛋清所致大鼠足跖肿胀、大鼠棉球所致肉芽肿、醋酸所致小鼠扭体反应均有显著抑制作用,其效果均优于阳性对照药JC(P<0.05)。结论:JDT具有良好的抗炎镇痛作用。

OBJECTIVE： To study the antiinflammatory and analgesic effect of Jingangteng dispersible tablet （JDT） . METHODS： The antiinflammatory effect of JDT was studied on pinna swelling model mice, the voix pedis swelling model rats and the cotton ball granuloma model rats; the writhing experiment in mice was done to study the analgesic effect of JDT, with Jingangteng capsule（JC） as a positive control. RESULTS： JDT significantly inhibited mice＇ s swelling of pinna induced by xylene, rats＇ swelling of the voix pedis induced by albumen, rats＇ granulomatous accrementition induced by cotton ball as well as mice＇s writhing response induced by acetic acid, with effects superior to those of J C（P 〈 0.05）. CONCLUSION： J DT has a satisfactory antiinflammatory and analgesic effect.