甲状腺激素异常变化在扩张型心肌病心力衰竭中的意义

Significance of thyroid hormone changes in heart failure of dilated cardiomyopathy

目的探讨扩张型心肌病心力衰竭患者甲状腺激素变化的意义。方法采用放免法检测66例扩张型心肌病心力衰竭患者及40名正常对照者的甲状腺功能。结果扩张型心肌病心力衰竭组与健康对照组相比,三碘甲腺原氨酸(T_3)降低,反三碘甲腺原氨酸(rT_3)升高。同时,随着NYHA心功能分组的加重,T_3逐渐降低,rT_3逐渐升高。结论正常甲状腺功能病态综合征广泛存在于扩张型心肌病心力衰竭患者中,并与心功能密切相关。

Objective To investigate the clinical significance of thyroid hormone changes in heart failure of dilated cardiomyopathy （DCM）. Methods 40 controls and 66 DCM patients were divided into three groups according to the degree of heart failure. Levels of thyroid hormones were detected by radioimmunoassay. Results In DCM patients, the level of triiodothyronine （T3） was lower than that in control group. The level of reverse T3 （rT3） increased markedly in DCM patients. There were great changes of T3 and rT3 among different degrees of heart failure. Conclusion T3 and rT3 levels may be taken as determinative indicators for reflecting the severity of heart failure of DCM.