摘要
胰岛素抵抗是糖尿病、高血压、肥胖症、动脉硬化等代谢综合征疾病代谢紊乱的基础,其发病机制除复杂的遗传因素和环境因素(年龄、肥胖、不同种族)外,胰岛素的靶器官及受体水平机制、脂肪源性细胞因子异常表达及对胰岛素信号通路影响、其他因素在胰岛素抵抗发生过程中都起着重要作用。
Insulin resistance is the basis of metabolic disorder in metabolic syndicome, such as dia- betes, hypertension, obesity, arteriosclerosis, and so on. Besides complex hereditary factor and environ- mental factors（age, obesity, racial difterence） in its pathogenesis, mechanism of insulin-targeted organs as well as receptors, abnormal expression of adipose-derived cytokines and its influquence on insulin sig- naling pathway and the other factors all play the impoamat role in the genesis of insulin resistance.
出处
《医学综述》
2007年第24期1997-1999,共3页
Medical Recapitulate
