脑钠素与左室舒张功能的关系

Relation of brain natriuretic peptide and left ventricular diastolic function

目的:探讨无症状和有症状左室舒张功能障碍患者血清脑钠素(BNP)水平变化及临床意义。方法:对经超声心动图检测符合心脏单纯左室舒张功能障碍的53例心血管病患者根据临床症状分为无症状左室舒张功能障碍组(无症状组)和有症状左室舒张功能障碍组(有症状组)。采用酶联免疫吸附法(ELISA)测定血清BNP水平,并与30例健康体检者(正常对照组)进行对比分析。结果:与正常对照组相比,无论有无症状,左室舒张功能障碍组BNP水平均明显升高,且有症状组比无症状组升高更明显(P<0.01)。结论:血清BNP水平升高可反映左室舒张功能障碍及其严重程度,对心功能不全的早期诊断具有重要临床价值。

Objective ：To investigate the change and clinic significance of serum brain natriuretic peptide （BNP） level in patents with left ventricular （LV） diastolic dysfunction. Methods ：53 patiens referred for echocardiography to evaluate the LV dysfunction. Patients with abnormal systolic function were excluded. Patients were classified as asymptomatic LV diastolic dysfunction group and symptomatic LV diastolic dysfunction group. Serum BNP concentration were measured with ELISA in 53 patients with LV diastolic dysfunction and 30 healthy persons as control group. Results ：Asymptomatic and symptomatic LV diastolic dysfunction groups had higher BNP level than control group（P〈0.01）. Patients with symptomatic LV diastolic dysfunction had higher BNP level than those with asymptomatic LV diastolic dysfunction（P〈0.01）. Conclusions ： BNP makes an useful indicator for LV diastolic function, It also is helpful to diagnosis of cardiac dysfunction.