胃食管喉气管反流动物实验初步验证

Evidence from Preliminary Animal Study for Gastroesophago-laryngotracheal Reflux

目的:试图从动物实验探讨胃食管喉气管综合征。方法:将4只远交群(SD)大鼠随机分为实验组和对照组,每组各2只。实验组在食管近段置入撑开器,以消除食管下端括约肌功能,封闭幽门远端以形成反流;对照组仅封闭幽门远端。两组制备完成后胃内注入亚甲蓝溶液1 m l,观察胃内容物反流情况。结果:实验组食管、咽部、口鼻腔和喉气管内腔均蓝染,对照组除部分食管蓝染外,余部位均未见蓝染。结论:实验结果揭示了作为胃食管喉气管综合征基础的胃食管喉气管反流的存在。

Objective： Exploring evidence tor gastroesophago-laryngeal reflux from a preliminary animal study. Methods： Four standard SD rats were divided into study group（ n = 2） and control group （n = 2 ）. In study group, a plastic extender with a trumpetshaped lower end was deployed into the gastroesophageal junction for dilatation of the cardia;In both groups,the pyroloos was ligated and 1 ml of ethyl blue was injected into the stomach. Results ： In the study group,various degree of blue staining was observed all the way from esophagus to pharynx,oro-nasal cavity,larynx and part of trachea;while in the control group, no blue staining was revealed except the lower esophagus. Conclusion：This study discloses the gastroesophago-laryngotracheal reflux,the basis for gastroesophagolaryngotracheal syndrome.