髓核组织工程学研究进展

Advance in Research of Nucleus Pulposus Tissue Engineering (review)

椎间盘退化是临床上一个重大的问题,椎间盘退化起自于椎间盘细胞以及髓核细胞外基质的变化。近年来,随着对椎间盘退变的分子学基础研究的进展,人们提出用生物对策来修复和恢复退变的椎间盘,其中一种很有希望的方法是应用组织工程的方法修复退变的椎间盘,恢复椎间盘组织的功能。作者就种子细胞、细胞支架和生长因子方面髓核组织工程学的研究进展进行综述。

Disc degeneration is a substantial clinical problem. Disc degeneration begins with a loss of disc cells and alterations in the extraeellular matrix of the nucleus pulposus （NP） cells. Recently, as the molecular basis of disc degeneration becomes increas- ingly understood, various biologic strategies to repair or regenerate the degenerative disc have been suggested. One promising approach for this problem involves the use of tissue engineering to regenerate the degenerative disc for achieving functional tissue repair. The authors reviewed the main progress of the NP tissue engineering from cells, scaffolds, growth factor.