奥沙拉秦的合成实验研究

Study on the Synthesis of Olsalazine

奥沙拉秦是一种新型抗溃疡性结肠炎药物。以水杨酸为原料经酯化、硝化、甲磺酰化、还原、重氮化偶合、水解反应制备。确定了还原反应的最佳工艺条件。反应总收率20%,产品纯度可达90%(wt)以上。

Olsalazine was a new anti-ulcerous colitis drug. It was preparedfrom salicylic acid by esterification, sulfonylation, deoxidize, diazotization coincidence and hydrolysis. The optimum conditions of deoxidize reaction were obtained. The total yield was 20% and the purity 90%（by weight）.