摘要
黏膜黏附材料使阴道黏膜给药系统更具有局部浓度高,作用时间长,减少给药次数和总量等优点。本文在讨论黏膜黏附机制的基础上,综述了聚丙烯酸类、纤维素类及壳聚糖等各种黏附材料在阴道给药中的应用及安全性评价。
In the field of mucoadhesive vaginal drug delivery system, mucoadhesive polymers are of considerable interest, which helps drugs to maintain a certain level locally, to extend drug residence time at the administration site and to reduce dosing frequency and the amount of drug administered. Here the characteristics and major application of mucoadhesive polymers like polyacrylic acids, chitosan and cellulose for vaginal drug delivery and their safety considerations are reviewed.
出处
《药学与临床研究》
2007年第6期437-440,共4页
Pharmaceutical and Clinical Research
关键词
黏膜黏附
机理
阴道
聚丙烯酸
壳聚糖
Mucoadhesion
Mechanism
Vagina
Polyacrylic acids
Chitosan