脑苷肌肽注射液(凯洛欣)治疗新生儿缺氧缺血性脑病疗效观察

The effect of cattle encephalon glycoside and ignotin injection on neonates with hypoxia-ischemia encephalopathy

目的：观察脑苷肌肽注射液（凯洛欣）治疗新生儿缺氧缺血性脑病（HIE）的疗效。方法：将患几分为治疗组（凯洛欣组）与对照组，两组病例均根据病情给予吸氧、止惊、降颅压及能量合剂等支持治疗和对症处理，并及时纠正酸中毒、低血压、低血糖等。治疗组给予凯洛欣2mL，加入100g·L^-1葡萄糖注射液20mL中静脉滴注，1次／d，7d为1个疗程，连用1～2个疗程。结果：治疗组62例中显效42例，有效15例，无效5例，总有效率91．93％。对照组50例中显效15例，有效22例，无效13例，总有效率74．0％。两组差异有显著性意义（P〈0．05）。结论：应用凯洛欣治疗新生儿缺氧缺血性脑病临床效果显著，能在短期内消除症状，提高疗效，促使受损脑细胞早日恢复，缩短病程且副作用少。

e.To investigation the effect of cattle encephalon glycoside and ignotin injection（CEGI） to sedative, intracranial pressure reduction, and energy mixture. The rectification of acidosis, hypotension and hypoglycemia was also same in the two groups according to patients＇ condition. Besides, in CEGI group, 2 mL CEGI was added into 10% GS 20 mL ivgtt qd for 7days in one period. Another 1 - 2 periods were applied continually. Results： The total efficiency in CEGI group was 91.9% （42 neonates improved obviously, 15 improved, and 5 had no effect in all 62 newborns）, compared with 74. 0% in control group （ 15 neonates improved obviously, 22 improved, and 13 had no effect in 50 newborns）, with significant statistic difference between two groups （ P 〈 0. 05 ）. Conclusion： There are obviously positive clinic benefits of CEGI in HIE therapy. CEGI can eliminate symptoms quickly, improve therapeutic effects, make impaired brain cell recover earlier with little side effects. This therapy deserves to be widely used in practice.