基因的瞄准器：基因靶向技术——评2007年诺贝尔生理学或医学奖

Gene Targeting:Technology of Gene Modifications Comment on The Nobel Prize in Physiology or Medicine 2007

2007年10月8日,美国科学家马里奥·卡佩奇和奥利弗·史密斯、英国科学家马丁·埃文斯因为"在涉及胚胎干细胞和哺乳动物DNA重组方面的一系列突破性发现"(即"基因靶向"技术)而获此殊荣,该技术在研究基因的功能以及建立人类疾病模型等方面开创了一个全新思维模式和技术手段。本文将就"基因靶向"技术作一简要介绍。

Americal scientists Mario R. Capecchi, Oliver Smithies and British scientist Martin J. Evans are jointly awarded the 2007 Nobel Laureates in Physiology or Medicine on 8 October, 2007 for their discoveries of ＂principles for introducing specific gene modifications in mice by the use of embryonic stem cells＂ （technology of gene targeting）. Gene targeting allows scientists to establish the roles of individual genes in health and disease. This article will introduce the techonology of ＂gene targeting＂.