岩舒注射液静脉滴注联合心包腔置管化疗治疗恶性心包积液

Clinical treatment of malignant pericardial effusion using Yanshu injection i.v and intra-pericardial catheterized chemotherapy

目的观察岩舒注射液联合心包腔置管低剂量顺铂多次化疗治疗恶性心包积液的价值。方法选择29例恶性心包积液患者分为治疗组与对照组。治疗组采用岩舒注射液联合心包腔置管顺铂腔内化疗;对照组仅予心包腔内置管顺铂腔内化疗。于治疗前后检测比较两组外周血T细胞亚群变化,并进行组间比较。结果心包积液的有效率治疗组略高于对照组(P>0.05),治疗组治疗后较治疗前CD3,CD4,CD4/CD8明显升高(P<0.05),Ⅰ～Ⅱ白细胞和血小板下降发生率治疗组明显低于对照组(P<0.05)。结论岩舒注射液联合经皮心包腔内置管化疗对恶心心包积液有效,且毒副反应低,可增强患者免疫力。

Objective To observe the clinical significance of Yanshu injeetion given intravenously in combination with multiple low-dose cisplatin given intrapericardially in malignant pericardial effusion. Methods In 29 patients with pericardial effusion of advanced cancer, 14 were as combination treatment group,catheterized and drained after pericardioeentresis, and were given Yanshu injection intravenously, then also cisplatin was injected into the the pericardial cavity for intra-pericardial chemotherapy. The other 15 patients only accepted cisplatin for intra-pericardial chemotherapy（as control group）. The T cell subgroups in peripheral blood of both groups were checked up before and after treatment respectively. Results The response rate of the combination treatment group was slightly higher than that of control group （P〉0.05）,but the CD4/CD8 value elevated statistically in the combination treatment group （P〈0.05）. Conclusion With pericardial effusion, the drain aud injecting cisplatin into pericardial cavity, in combination with Yanshu injection given intravenously, may be a effective treatment method with lower toxicities and can enhance the patieut＇s immune fanction.